Core Theme:
The book examines humanity’s evolutionary journey—from primitive beginnings to the AI era—through the lens of radical transformation. Bikalpa argues that progress demands fundamental shifts (“changing the seed to change the fruit”) rather than incremental adjustments.

Pillar:
Critique of Conservatism:
Exposes how anti-science ideologies, superstition, and discriminatory traditions perpetuate inequality and stagnation.  
Science as Liberation:
Positions scientific innovation and critical thinking as essential for societal advancement, equity, and overcoming “failed states”.  

Role of Changemakers:
Highlights “extraordinary individuals” whose pioneering experiments disrupt the status quo to establish new social orders .  Provocative Insights:   
“A country becomes great when its rulers are creative, visionary, and dedicated to national interest. It fails when led by the visionless and corrupt” .  
Life:
“Life is an unpublished book requiring constant editing” – reflecting the book’s emphasis on perpetual reinvention of life. 
 Key Quotes:
– A country becomes miserable when guided by visionless leaders.  
– Anti-science policy is a policy against progress, equality, and facts.  
-Citizens lose hope in a failed country where politics betrays their future.
-Changing fruits require changing seeds.

Significance:
Published by Shikha Books (Nepal), ´Antithesis` synthesizes Bikalpa’s interdisciplinary expertise into a manifesto for Nepal and beyond, urging systemic change through science and visionary leadership.